What common condition would you expect Lynne to have with Cushing syndrome?

Enhance your knowledge on endocrine and metabolic disorders with the Dunphy Practice Test. Unlock expert-level understanding with detailed flashcards and multiple choice questions, complete with hints and explanations.

When considering conditions commonly associated with Cushing syndrome, generalized increased pigmentation of the skin is a notable feature. Cushing syndrome occurs due to excessive cortisol levels in the body, which can lead to various skin changes. One of these changes is the development of broad areas of hyperpigmentation, especially in areas subject to friction such as elbows, knees, and the neck. This occurs as a response to increased adrenocorticotropic hormone (ACTH) levels that can stimulate melanocyte activity, thereby resulting in darkened skin pigmentation.

In contrast, while onychomycosis refers to a fungal infection of the nails, it is not directly associated with Cushing syndrome and does not represent a hallmark of this condition. Hair loss can occur in Cushing syndrome, but it's less characteristic than the skin pigmentation changes. Similarly, excitability and nervousness may be observed in some patients but are not definitive markers of Cushing syndrome. The most pronounced and commonly linked skin manifestation is the generalized increase in pigmentation, which signifies the endocrine disruption caused by the elevated cortisol.

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